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KMID : 0861120090130020089
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Korean Journal of Oriental Preventive Medicine
2009 Volume.13 No. 2 p.89 ~ p.102
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Effects of Germanium-fortified Tricholoma matsutake Mycelium and Yeast on Blood Glucose and Serum Lipid in Streptozotocin-Induced Diabetic Rats
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Kim Wan-Gyeom
Kim Hae-Ja
Chong Myongsoo
Cho Hwa-Eun
Choi Yun-hee
Lee Ki-Nam
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Abstract
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Objectives:The purpose of this study was evaluated hypoglycemic effect of culture broth of germanium-fortified Tricholoma matsutake mycelium and yeast.
Methods: We examined α-glucosidase inhibitory activity, blood glucose level, concentration of serum lipid, and serum metabolic variables of Tricholoma matsutake mycelium and yeast fortified Germanium. in streptozotocin induced diabetic rat.
Results:In the α-glucosidase inhibitory activity, germanium-fortified yeast was significantly higher than germanium-fortified Tricholoma matsutake mycelium. The hypoglycemic effects of germanium- fortified Tricholoma matsutake mycelium was higher than germanium-fortified yeast. The activity of alkaline phosphatase(ALP), aspartate aminotransferase(AST) and alanine aminotransferase(ALT) was significantly lower in the germanium-fortified Tricholoma matsutake mycelium and yeast than in diabetic control(DC) group and diabetic positive control(PC) group. The concentration of total cholesterol and triglyceride of germanium-fortified yeast was significantly lower than germanium-fortified Tricholoma matsutake mycelium, DC group and PC group.
Conclusions:The results suggest that germanium-fortified Tricholoma matsutake mycelium and yeast have improvement effects in blood glucose, serum lipid and liver function.
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KEYWORD
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organic germanium, Tricholoma matsutake mycelium, Yeast, diabetes mellitus, Streptozotocin(STZ)
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